NeoGen Plasma: A Scientific Approach to Collagen Induction and Dermal Repair

When we talk about “skin rejuvenation,” it’s easy to picture glowing complexions and smoother texture, but beneath the surface, true regeneration begins with controlled cellular stress. NeoGen Plasma isn’t just another device in the aesthetic toolkit; it’s a technology rooted in physics, chemistry, and the body’s natural repair biology. To understand why NeoGen stands apart, we have to start with one element: nitrogen.

The Mechanism of Nitrogen Plasma: Energy Transformation for Dermal Repair

NeoGen uses medical-grade nitrogen gas that’s converted into plasma energy, the fourth state of matter. When this plasma comes into contact with the skin, it releases a precise burst of thermal energy that interacts with the epidermis and dermis in a completely unique way. Unlike laser or radiofrequency devices, NeoGen plasma doesn’t depend on targets within the skin, such as pigment or water, to deliver energy. Instead, it transfers its energy uniformly and non-fractionated, treating the entire skin surface. This creates a consistent, full-surface rejuvenation rather than treating only small, separated zones. (Fitzpatrick et al., 2010)

But it’s what happens after that controlled plasma interaction that’s truly extraordinary.

Reactive Oxygen Species: Key Biological Messengers in Tissue Renewal

When the plasma pulse meets the skin, it triggers the formation of Reactive Oxygen Species (ROS) molecules like superoxide, hydrogen peroxide, and hydroxyl radicals. While these sound harmful, in controlled doses, they play a vital signalling role in tissue repair.(Roy et al., 2003; Schäfer & Werner, 2008).

Think of ROS as biochemical “messengers.” They alert the skin that mild stress has occurred, activating cellular defence pathways and growth factors that stimulate regeneration. Controlled ROS levels lead to:

• Upregulated fibroblast activity, promoting new collagen and elastin synthesis.

• Accelerated epidermal turnover, resulting in smoother, brighter skin.

• Enhanced antioxidant defences, improving resilience against future damage.

  
  

In other words, NeoGen doesn’t damage the skin, it teaches itself to repair and strengthen.

The Biological Role of Nitric Oxide in Tissue Healing

Another critical molecule generated by plasma is Nitric Oxide (NO), often called the “molecule of life.” It’s a key regulator of vascular tone, immune response, and wound healing.  (Emmert et al., 2013; Schäfer & Werner, 2008).

During a NeoGen treatment, Nitric Oxide diffuses into the skin and performs several regenerative tasks:

• Improves microcirculation by dilating capillaries, enhancing oxygen and nutrient delivery to the tissue.

• Modulates inflammation, balancing the healing response and reducing post-treatment downtime.

• Stimulates fibroblast migration and keratinocyte proliferation, two essential processes in skin renewal.

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This combination of ROS and NO creates an optimal healing environment, not only for rejuvenation but for improving overall skin health and barrier function.

NeoGen’s brilliance lies in its ability to create a controlled thermal injury without ablation or carbonisation. This “plasma cascade” reaches from the surface down to the dermis, initiating a full-thickness response while keeping the skin intact, a feature known as the “neodermal remodelling effect.” (Fitzpatrick et al., 2010).

As the skin heals, it rebuilds stronger, denser collagen networks, refines pore structure, reduces pigmentation irregularities, and visibly tightens. Over the following weeks and months, fibroblast activity continues, leading to progressive improvement and long-lasting results that mimic a natural “reset” of the skin’s architecture.

Why It Feels Different and Why the Results Last

Because NeoGen plasma doesn’t create open wounds or channels, it preserves a biological dressing, a layer of denatured protein that protects and aids recovery. Beneath this layer, the skin regenerates in an oxygen-rich, nitric oxide-enhanced environment, perfectly balanced for cellular renewal.

The outcome? Not just temporary plumpness or surface radiance but a biochemical rejuvenation, where the skin behaves as if it’s younger. It’s regeneration by design, powered by nitrogen and the body’s own molecular intelligence.

Mechanism	Molecular Action	Skin Result
Nitrogen Plasma	Delivers uniform, non-fractionated thermal energy	Stimulates full-surface regeneration
Reactive Oxygen Species (ROS)	Signals controlled cellular stress	Collagen induction, antioxidant defence
Nitric Oxide (NO)	Enhances blood flow, modulates inflammation	Faster healing, stronger skin barrier

References

1. Fitzpatrick R, Bernstein E, Brown T, Andrews P, Goldenberg D. Nitrogen Plasma Skin Regeneration: Clinical and Histologic Evaluation of a New Technology for Skin Rejuvenation. Dermatologic Surgery. 2010;36(8):1223–1232.

2. Fridman G, Friedman G, Gutsol A, Shekhter AB, Vasilets VN, Fridman A. Applied Plasma Medicine. Plasma Processes and Polymers. 2008;5(6):503–533.

3. Roy S, Khanna S, Nallu K, Hunt TK, Sen CK. Oxygen Sensing and the Inflammatory Response in Wound Healing. Free Radical Biology & Medicine. 2003;33(8):1047–1056.

4. Schäfer M, Werner S. Oxidative Stress in Normal and Impaired Wound Repair. Pharmacological Research. 2008;58(2):165–171.

Emmert S, Brehmer F, Hänßle H, Helmke A, Mertens N, Ahmed R, Simon D, Wandke D, Maus-Friedrichs W, Däschlein G. Atmospheric Pressure Plasma in Dermatology: Ulcus Treatment and Skin Disinfection. Clinical Plasma Medicine. 2013;1(1):24–29.

Offer on until the 15th October - LIMITED TIME TO BOOK!

When you purchase a course of 3 NeoGen sessions for the face, you'll receive the neck completely free, saving £2,200.

OFFER DETAILS

3 NeoGen Plasma treatments (face)

Complimentary Neck area included

TOTAL: £2,200

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