How do exosomes function?

Exosomes, minute extracellular vesicles naturally produced by nearly every cell in the body, serve as crucial agents in intercellular communication. These tiny sacs, with a lipid casing, facilitate the transfer of signaling molecules like proteins and genetic material between cells, thereby influencing biological processes. By identifying cells in need of repair, they initiate and promote the repair process.

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What outcomes can one anticipate from exosomes?

Exosomes yield results that evoke remarks such as "you look revitalized" rather than "what cosmetic procedures have you undergone?" They enhance the skin's appearance by imparting a fresher, brighter, and smoother complexion, addressing issues such as uneven tone and texture, acne scars, enlarged pores, and wrinkles. By stimulating the natural repair mechanisms of skin cells, exosomes prompt increased collagen and elastin production, expedite wound healing, and reduce irregular pigment production.

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EXO E, a brand of plant-derived exosomes endorsed by Dr. Sophie Shotter, has shown promise in significantly boosting elastin production while enhancing collagen and hyaluronic acid levels. Additionally, it may mitigate side effects such as inflammation resulting from more invasive acne and burn treatments, making it a favorable complementary treatment option.

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Are exosomes similar to stem cells?

Not precisely. Although both exosomes and stem cells are known for their skin rejuvenating properties, exosomes differ in that they are not living cells (lacking a nucleus) and can be obtained from various sources. Similarly, liposomes, which aid in delivering ingredients into the skin via encapsulation, are simpler structures capable of containing either water-loving or water-hating ingredients.

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What are the sources of exosomes utilized for skin rejuvenation?

Human-derived: Most recent research on exosomes has been conducted in countries like Korea, where the use of human-derived exosomes is legal. These exosomes are purportedly the most potent, yielding superior results. However, they also pose ethical concerns due to regulations in the UK regarding human-derived ingredients and the potential risk of DNA contamination, as they are often sourced from infants or young individuals. Extensive processing is required to prepare human-derived exosomes for use, often necessitating the addition of key components such as vitamins and growth factors.

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Animal-derived: Derived from colostrum, the initial milk produced by cattle, bovine-derived exosomes are gaining traction in aesthetics as a viable alternative to human sources. However, the process of obtaining animal-derived exosomes may compromise vital ingredients such as vitamins and growth factors, necessitating their supplementation. Concerns also exist regarding the potential for cross-contamination of animal-to-human DNA.

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Plant-derived: Recognized as the legally acceptable form of exosomes in the UK, plant-derived exosomes are often sourced from roses. However, human cell signaling is more intricate compared to plants, necessitating the combination of multiple plant sources for optimal results. Recent studies suggest that absorption of plant-derived exosomes could be superior to other sources.

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Is the use of human-derived exosomes for skin rejuvenation legal in the UK?

The legality of using human-derived exosomes for skin rejuvenation in the UK is subject to debate. While some practitioners argue that topical application of exosomes is permissible, concerns arise when exosomes are used topically in conjunction with procedures like micro-needling, designed to enhance skincare penetration. Moreover, under UK and European regulations, the use of human-derived ingredients is strictly prohibited, rendering the use of human-derived exosomes illegal, even for topical applications. The ambiguity surrounding this issue underscores the importance of careful consideration before undergoing such treatments.

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Do exosomes yield immediate results?

As exosomes stimulate the skin's natural repair processes, noticeable results are not immediate. The most significant improvements typically manifest 3-6 weeks post-treatment, attributable to increased collagen and elastin production. However, their anti-inflammatory properties can swiftly reduce the downtime associated with other cosmetic treatments!

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Is exosome treatment painful?

They administered using a microneedling device, with minimal downtime and very comfortable.

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How long do the results of exosome treatments last?

Exosomes are believed to remain active in the skin for up to six to eight months following treatment, contributing to sustained improvements in skin quality.